A drug-self-gated and tumor microenvironment-responsive mesoporous silica vehicle: “four-in-one” versatile nanomedicine for targeted multidrug-resistant cancer therapy-Reference-Cited by-同舟云学术

A drug-self-gated and tumor microenvironment-responsive mesoporous silica vehicle: “four-in-one” versatile nanomedicine for targeted multidrug-resistant cancer therapy

Published:2017 Issue:43 Volume:9 Page:17063-17073
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Cheng Wei¹²³⁴⁵,Liang Chaoyu¹²³⁴⁵,Wang Xusheng¹²³⁴⁵,Tsai Hsiang-i¹²³⁴⁵,Liu Gan⁶⁷⁸⁹,Peng Yunmei¹²³⁴⁵,Nie Junpeng¹²³⁴⁵,Huang Laiqiang¹²³⁴⁵,Mei Lin⁶⁷⁸⁹^ORCID,Zeng Xiaowei¹²³⁴⁵^ORCID

Affiliation:

1. The Shenzhen Key Lab of Gene and Antibody Therapy

2. The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology

3. and Division of Life and Health Sciences

4. Graduate School at Shenzhen

5. Tsinghua University

6. School of Pharmaceutical Sciences (Shenzhen)

7. Sun Yat-sen University

8. Guangzhou 510275

9. P.R. China

Abstract

A smart nanoplatform which co-delivers doxorubicin and P-gp siRNA exhibited an excellent synergistic effect for targeted multidrug-resistant cancer therapy.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NR/C7NR05450E

Reference52 articles.

1. Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas

2. Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy