A green bio-organic catalyst (taurine) promoted one-pot synthesis of (<i>R</i>/<i>S</i>)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches-Reference-Cited by-同舟云学术

A green bio-organic catalyst (taurine) promoted one-pot synthesis of (R/S)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches

Published:2024 Issue:13 Volume:14 Page:9300-9313
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Parmar Mehul P.¹^ORCID,Vala Disha P.¹^ORCID,Bhalodiya Savan S.¹^ORCID,Upadhyay Dipti B.¹^ORCID,Patel Chirag D.¹^ORCID,Patel Subham G.¹^ORCID,Gandholi Srinivasa R.²,Shaik Althaf H.²^ORCID,Miller Amy Dunne³^ORCID,Nogales Joaquina³^ORCID,Banerjee Sourav³^ORCID,Padrón José M.⁴^ORCID,Amri Nasser⁵^ORCID,Kandukuri Nagesh Kumar²^ORCID,Patel Hitendra M.¹^ORCID

Affiliation:

1. P. G. Department of Chemistry, Sardar Patel University, Near University Circle, Vallabh Vidyanagar, 388120, Gujarat, India

2. YMC Application Lab, Plot No. 78/A/6, Phase VI, Industrial Park Jeedimetla, Gajularamaram Village, Quthbullapur, Medchal, Hyderabad-500055, Telangana, India

3. Department of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, UK

4. BioLab, Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain

5. Department of Chemistry, College of Science, Jazan University, P.O. Box 2097, Jazan 45142, Saudi Arabia

Abstract

Twenty-three new derivatives of (R/S)-TDHPM-5-carboxanilide have been synthesized with up to 99% yield. All racemates were separated using chiral HPLC (Prep LC) which provided up to 99.99% purity. AC was determined using circular dichroism spectra.

Funder

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01391C

Reference42 articles.

1. Design, Synthesis, Analysis, Evaluation of Cytotoxicity Against MCF-7 Breast Cancer Cells, 3D QSAR Studies and EGFR, HER2 Inhibition Studies on Novel Biginelli 1,4-Dihydropyrimidines

2. Novel Biginelli dihydropyrimidines with potential anticancer activity: A parallel synthesis and CoMSIA study

3. A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-f]quinoline]-8,5′-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolines via selective multiple C–C bond formation under metal-free conditions

4. Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-b]quinolinones

5. Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones

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