Reprogramming of the tumor microenvironment using a PCN-224@IrNCs/<scp>d</scp>-Arg nanoplatform for the synergistic PDT, NO, and radiosensitization therapy of breast cancer and improving anti-tumor immunity-Reference-Cited by-同舟云学术

Reprogramming of the tumor microenvironment using a PCN-224@IrNCs/d-Arg nanoplatform for the synergistic PDT, NO, and radiosensitization therapy of breast cancer and improving anti-tumor immunity

Published:2023 Issue:25 Volume:15 Page:10715-10729
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zou Yi-Ming¹,Li Rong-Tian¹,Yu Lei²,Huang Ting¹,Peng Jian¹,Meng Wei¹,Sun Bin¹^ORCID,Zhang Wen-Hua³^ORCID,Jiang Zhi-Hong⁴^ORCID,Chen Jun¹^ORCID,Chen Jin-Xiang¹^ORCID

Affiliation:

1. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, People's Republic of China

2. Department of Dermatology, Zhujiang Hospital of Southern Medical University, No. 253 Gongye Avenue, Guangzhou 510091, People's Republic of China

3. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China

4. Macau University of Science and Technology, Taipa, Macau 999078, People's Republic of China

Abstract

By reprogramming the tumor microenvironment and integrating multiple therapeutic modalities, we have successfully constructed an effective, safe, and multifunctional radiosensitization nanoplatform for enhancing anti-tumor immunity.

Funder

Guangzhou Municipal Science and Technology Project

National Natural Science Foundation of China

Guangdong Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR01050C

Reference55 articles.

1. Radiotherapy and radiosensitization in breast cancer: Molecular targets and clinical applications