Biotin-decorated hollow gold nanoshells for dual-modal imaging-guided NIR-II photothermal and radiosensitizing therapy toward breast cancer

Author:

Chen Yongjian1,Meng Wei1,Chen Ming2ORCID,Zhang Lianying3,Chen Mingwa1,Chen Xiaotong1,Peng Jian1,Huang Naihan1,Zhang Wenhua4ORCID,Chen Jinxiang1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China

2. The People's Hospital of Gaozhou, Maoming 525200, China

3. School of Pharmacy Sciences, Southwest Medical University, Luzhou 646000, China

4. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China

Abstract

The novel structure of the hollow gold shell has an ideal X-ray deposition capacity, which ensures the sensitizing effect of radiotherapy. The immunogenic cell death pathway is activated by NIR-II photothermal therapy in conjunction with radiotherapy.

Funder

Guangdong Provincial Department of Science and Technology

National Natural Science Foundation of China

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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