Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)-Reference-Cited by-同舟云学术

Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)

Published:2021 Issue:3 Volume:50 Page:1480-1494
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Cooper Bethany M.¹²³⁴⁵^ORCID,Iegre Jessica¹²³⁴⁵^ORCID,O' Donovan Daniel H.⁶⁷⁴⁵^ORCID,Ölwegård Halvarsson Maria⁸⁹¹⁰¹¹⁷,Spring David R.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Lensfield Road

4. Cambridge

5. UK

6. Oncology R&D

7. AstraZeneca

8. Medicinal Chemistry

9. Research and Early Development Cardiovascular

10. Renal and Metabolism

11. BioPharmaceuticals R&D

Abstract

A tutorial review showcasing how peptide–drug conjugates can offer the versatility needed for a successful drug discovery approach, their problems and future opportunities.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CS/D0CS00556H

Reference50 articles.

1. The Future of Peptide-based Drugs

2. Impact Story: Developing the Tools to Evaluate Complex Drug Products: Peptides, https://www.fda.gov/drugs/regulatory-science-action/impact-story-developing-tools-evaluate-complex-drug-products-peptides , accessed 28 August 2020

3. Strategic Approaches to Optimizing Peptide ADME Properties

4. Oral Administration of Peptide-Based Drugs: Beyond Lipinski's Rule

5. Advances in oral peptide therapeutics

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