A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N′-dioxide

A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N′-dioxide–metal complexes

Published:2017 Issue:2 Volume:8 Page:1238-1242
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lian Xiangjin¹²³⁴⁵,Lin Lili¹²³⁴⁵,Fu Kai¹²³⁴⁵,Ma Baiwei¹²³⁴⁵,Liu Xiaohua¹²³⁴⁵,Feng Xiaoming¹²³⁴⁵

Affiliation:

1. Key Laboratory of Green Chemistry & Technology

2. Ministry of Education

3. College of Chemistry

4. Sichuan University

5. Chengdu 610064

Abstract

An efficient asymmetric Mannich-type reaction between α-tetralone-derived β-keto esters/amides and 1,3,5-triaryl-1,3,5-triazinanes was realized catalyzed by chiral N,N'–dioxide-Ni(ii)/Mg(ii) complexes.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03902B

Reference51 articles.

1. Modern Variants of the Mannich Reaction

2. Ueber ein Kondensationsprodukt aus Formaldehyd, Ammoniak und Antipyrin

3. Further advances in the chemistry of mannich bases

4. M. Tramontini and L.Angiolini, Mannich-Bases, Chemistry and Uses, CRC, F. L. Boca Raton, 1994

5. Mannich bases in polymer chemistry

Cited by 78 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells;Anticancer Research;2024-02-29

2. Shifting Access from Pyrimidine‐Spirofused to Fused Benzoheterocycles by Modifying the Activated Group Position;Advanced Synthesis & Catalysis;2024-02-05

3. Substituent-controlled divergent cyclization reactions of benzo[c][1,2]dithiol-3-ones and hexahydro-1,3,5-triazines;Organic Chemistry Frontiers;2024

4. [2+2+1+1] Cycloaddition Reaction of 1,3,5‐Triazinanes with Methylene Compounds: Approach to Hexahydropyrimidines;Advanced Synthesis & Catalysis;2023-10-12

5. A New Catalytic Method for the Synthesis of Cyclic Azaperoxides with High Cytotoxic Activity;ChemistrySelect;2023-10-02