Affiliation:
1. Institute of Petrochemistry and Catalysis, Ufa Federal Research Center Russian Academy of Sciences 141 Prospekt Oktyabrya Ufa 450075 Russian Federation
2. N. D. Zelinsky Institute of Organic Chemistry 47 Leninsky prospekt Moscow 119991 Russian Federation
Abstract
AbstractAn efficient method has been developed for the synthesis of N‐aryl‐1,2,4‐dioxazolidines, N‐aryl‐tetraoxaspiroalkanes, and N‐aryl‐hexaoxadispiroalkanes by cycloaminomethylation of OH acids (hydrogen peroxide, gem‐bis‐hydroperoxides, and 1,1′‐peroxybis(1‐hydroperoxycycloalkanes)) with 1,3,5‐triaryl‐1,3,5‐triazinanes in the presence of lanthanide catalysts. The eight‐membered azadiperoxides were shown to exhibit a high cytotoxic activity against Jurkat, K562, and U937 tumor cells and Hek296 immortalized normal cells. The cytotoxic activity of Fe(II)‐treated azadiperoxides against Jurkat tumor cells was studied; these compounds were shown to in Keywords: Catalysis; Cycloaminomethylation; Hydrogen peroxide; Gem‐bis‐hydroperoxides; 1,1′‐Peroxy‐bis(1‐hydroperoxycycloalkanes); Azaperoxides; Cytotoxic activity initiate cell autophagy.
Funder
Russian Science Foundation