Dimethylzinc-mediated enantioselective addition of terminal alkynes to 1,2-diketones using perhydro-1,3-benzoxazines as ligands
Author:
Affiliation:
1. Instituto CINQUIMA and Departamento de Química Orgánica
2. Facultad de Ciencias
3. Universidad de Valladolid
4. 47011 Valladolid
5. Spain
Abstract
A highly regio- and enantioselective dimethylzinc-mediated monoalkynylation of 1,2-diketones in the presence of a chiral perhydro-1,3-benzoxazine is described.
Funder
Junta de Castilla y León
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00249J
Reference71 articles.
1. The Catalytic Enantioselective Construction of Molecules with Quaternary Carbon Stereocenters
2. Asymmetric Synthesis of Tertiary Alcohols and α-Tertiary Amines via Cu-Catalyzed C−C Bond Formation to Ketones and Ketimines
3. Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines
4. Enantioselective Catalytic Formation of Quaternary Stereogenic Centers
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