Modular synthesis of cyclic β-difluoroamines-Reference-Cited by-同舟云学术

Modular synthesis of cyclic β-difluoroamines

Published:2024 Issue:60 Volume:60 Page:7701-7704
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Charlesworth Natalie G.¹^ORCID,Arunprasath Dhanarajan¹^ORCID,Graham Mark A.²^ORCID,Argent Stephen P.¹^ORCID,Datsenko Oleksandr P.³,Mykhailiuk Pavel K.³⁴^ORCID,Denton Ross M.¹^ORCID

Affiliation:

1. School of Chemistry, GlaxoSmithKline Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, 6 Triumph Road, Nottingham NG7 2GA, UK

2. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, UK

3. Enamine Ltd, Winston Churchill Str. 78, 02094 Kyiv, Ukraine

4. Chemistry Department, Taras Shevchenko National University of Kyiv, Volodymyrska 64, 01601 Kyiv, Ukraine

Abstract

We report a new synthesis of cyclic β-fluoroalkyl amines using a photoredox-catalysed cyclisation which can be run in batch and flow-mode.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00640B

Reference25 articles.

1. The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

2. Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

3. Fluorine in health care: Organofluorine containing blockbuster drugs

4. Applications of Fluorine in Medicinal Chemistry

5. Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

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