Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer – synthesis, physicochemical characterisation and in vitro evaluation-Reference-Cited by-同舟云学术

Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer – synthesis, physicochemical characterisation and in vitro evaluation

Published:2016 Issue:13 Volume:4 Page:2242-2252
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Fitzgerald Kathleen A.¹²³⁴,Rahme Kamil⁵⁶⁷⁸⁹,Guo Jianfeng¹²³⁴,Holmes Justin D.¹⁰¹¹³¹²⁴,O'Driscoll Caitriona M.¹²³⁴

Affiliation:

1. Pharmacodelivery Group

2. School of Pharmacy

3. University College Cork

4. Ireland

5. Department of Sciences

6. Faculty of Natural and Applied Science

7. Notre Dame University

8. Louaize

9. Lebanon

10. Department of Chemistry and the Tyndall National Institute

11. Materials Chemistry and Analysis Group

12. Cork

Abstract

The surface of cationic gold nanoparticles was modified with the anisamide targeting ligand and successfully mediated siRNA uptake into prostate cancer cells via binding to the sigma receptor.

Funder

Irish Research Council

Science Foundation Ireland

Irish Cancer Society

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TB/C6TB00082G

Reference53 articles.

1. The role of transcription factors in prostate cancer and potential for future RNA interference therapy

2. Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

3. Anisamide-targeted cyclodextrin nanoparticles for siRNA delivery to prostate tumours in mice

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