Origin of non-linearity in phase solubility: solubilisation by cyclodextrin beyond stoichiometric complexation-Reference-Cited by-同舟云学术

Origin of non-linearity in phase solubility: solubilisation by cyclodextrin beyond stoichiometric complexation

Published:2016 Issue:22 Volume:18 Page:15205-15217
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Nicol Thomas W. J.¹²³⁴⁵,Matubayasi Nobuyuki⁶⁷⁸⁹¹⁰,Shimizu Seishi¹²³⁴⁵

Affiliation:

1. York Structural Biology Laboratory

2. Department of Chemistry

3. University of York

4. York YO10 5DD

5. UK

6. Division of Chemical Engineering

7. Graduate School of Engineering Science

8. Osaka University

9. Toyonaka

10. Japan

Abstract

The low solubility of drugs, which poses a serious problem in drug development, can in part be overcome by the use of cyclodextrins (CDs) and their derivatives.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science, and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP01582D

Reference58 articles.

1. Strategies to Address Low Drug Solubility in Discovery and Development

2. Improvement in solubility and dissolution rate of flavonoids by complexation with β-cyclodextrin

3. Study of the solubility, antioxidant activity and structure of inclusion complex of vanillin with β-cyclodextrin

4. Solubility and stability of taxol: effects of buffers and cyclodextrins

5. Solubility Enhancement of Flavonols in the Inclusion Complex with Thioether-bridged Dimeric β-Cyclodextrins

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