Design, synthesis, characterization, in vitro screening, molecular docking, 3D-QSAR, and ADME-Tox investigations of novel pyrazole derivatives as antimicrobial agents-Reference-Cited by-同舟云学术

Design, synthesis, characterization, in vitro screening, molecular docking, 3D-QSAR, and ADME-Tox investigations of novel pyrazole derivatives as antimicrobial agents

Published:2022 Issue:6 Volume:46 Page:2747-2760
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Chalkha Mohammed¹^ORCID,Akhazzane Mohamed¹²^ORCID,Moussaid Fatima Zahrae³,Daoui Ossama⁴,Nakkabi Asmae¹,Bakhouch Mohamed¹⁵^ORCID,Chtita Samir⁶^ORCID,Elkhattabi Souad⁴,Housseini Abdelilah Iraqi³,El Yazidi Mohamed¹^ORCID

Affiliation:

1. Engineering Laboratory of Organometallic and Molecular Materials and Environment (LIMOME), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796 (Atlas), 30000 Fez, Morocco

2. Université Sidi Mohamed Ben Abdellah, Cité de l’innovation, Fès, Morocco

3. Laboratory of Biotechnology, Environment, Agri-Food, and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA), 30050 Fez, Morocco

4. Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, Fez, Morocco

5. Laboratory of Bioorganic Chemistry, Department of Chemistry, Faculty of Sciences, Chouaïb Doukkali University, P.O. Box 24, 24000 El Jadida, Morocco

6. Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, B.P. 7955, Casablanca, Morocco

Abstract

Novel pyrazoles were synthesized and evaluated for their antimicrobial activity. Molecular docking, 3D-QSAR, drug-likeness property and ADME-Tox studies were performed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ05621B

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