Synthesis, Characterization, Antimicrobial and DFT Studies of Novel Quinolino‐Pyrazole Derivatives

Author:

Dayananda P.1,Nayak Janardhana2ORCID,Kudva Jyothi3,Chethan D. M.2,D'Souza Vineetha Telma4

Affiliation:

1. Department of Chemistry Excellent Science and Commerce P.U. College Moodabidri, Mangaluru, Karnataka India

2. Department of Chemistry NMAM Institute of Technology (NMAMIT) Nitte (Deemed to be University) Nitte-574 110 Udupi District, Karnataka India

3. Department of Chemistry St. Joseph Engineering College (Affiliated to Visvesvaraya Technological University, Belagavi) 575 028 Mangaluru India

4. Department of Chemistry M.I.T.E. (Affiliated to Visvesvaraya Technological University, Belagavi) 574 225 Moodbidri India

Abstract

AbstractSynthesis of novel (E)‐N‐(4‐(substituted)benzylidene)‐6‐substituted‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carbothioamides/carboxamides was achieved by the condensation of 6‐substituted‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carbothioamides/carboxamides with substituted benzaldehydes in alcoholic medium in the presence of acetic acid. The structures of synthesized compounds are assigned on the basis of FT IR, 1H NMR, 13C NMR and Mass Spectral data. The compounds are subjected for their antibacterial, antifungal and DFT studies. Compounds, (E)‐6‐chloro‐N‐(4‐(dimethylamino)benzylidene)‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carbothioamide (5 b), (E)‐6‐chloro‐N‐(4‐(dimethylamino)benzylidene)‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carboxamide (5 f), and (E)‐6‐chloro‐N‐(4‐hydroxybenzylidene)‐1H‐pyrazolo[3,4‐b]quinoline‐1‐carboxamide (5 j) possessed pronounced antibacterial and antifungal activities due to their chemical structure.

Publisher

Wiley

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