Mechanism of the Paal–Knorr reaction: the importance of water mediated hemialcohol pathway-Reference-Cited by-同舟云学术

Mechanism of the Paal–Knorr reaction: the importance of water mediated hemialcohol pathway

Published:2015 Issue:107 Volume:5 Page:88353-88366
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abbat Sheenu¹²³⁴,Dhaked Devendra⁵²³⁴,Arfeen Minhajul⁵²³⁴,Bharatam Prasad V.⁵²³⁴

Affiliation:

1. Department of Pharmacoinformatics

2. National Institute of Pharmaceutical Education and Research

3. S.A.S. Nagar

4. India

5. Department of Medicinal Chemistry

Abstract

The mechanism of the Paal–Knorr reaction was explored using quantum chemical methods. Hydronium ion catalysed hemialcohol pathway has been established as the preferred mechanistic route for the Paal–Knorr formation of furan, pyrrole and thiophene.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA16246G

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