Recent Advances in Synthetic Methods for 2H‐Pyrroles

Author:

Choi Seoung‐Mi1,Kim Ju Hyun1ORCID

Affiliation:

1. Department of Chemistry(BK 21 Four) Gyeongsang National University Jinju 52828 Korea

Abstract

AbstractThe compound, 2H‐pyrrole, is a key scaffold contained in natural products, bioactive compounds, pharmaceuticals, and organic functional materials. However, the development of efficient synthetic strategies for 2H‐pyrroles is challenging. This is because 2H‐pyrroles, owing to their nonaromatic nature, are easily converted into the thermodynamically more stable 1H‐pyrroles. Recently, efficient and straightforward synthetic strategies for 2H‐pyrroles have been developed, including the dearomatization of 1H‐pyrrole, oxidation of pyrrolines or pyrrolidines, ring construction via catalytic cycloaddition, and rearrangement of 3H‐pyrroles. In this review, we summarize the progress in the research on 2H‐pyrrole synthesis since 2000 and briefly discuss the synthesis reaction mechanisms.

Funder

National Research Foundation

Publisher

Wiley

Subject

General Chemistry

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