Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity

Author:

Zhou Ying1ORCID,Yuan Shuofeng234,Xiao Fan5,Li Hongyan1,Ye Ziwei6,Cheng Tianfan7,Luo Cuiting2,Tang Kaiming2,Cai Jianpiao2,Situ Jianwen2,Sridhar Siddharth2348,Chu Wing-Ming9,Tam Anthony Raymond9,Chu Hin2,Che Chi-Ming1ORCID,Jin Lijian7ORCID,Hung Ivan Fan-Ngai39,Lu Liwei5,Chan Jasper Fuk-Woo234810ORCID,Sun Hongzhe1ORCID

Affiliation:

1. Department of Chemistry, State Key Laboratory of Synthetic Chemistry, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

2. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

3. Department of Infectious Diseases and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China

4. Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, China

5. Department of Pathology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong SAR, China

6. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

7. Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, Hong Kong, China

8. Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China

9. Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

10. Academician Workstation of Hainan Province, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

Abstract

Uncovering how host metal(loid)s mediate the immune response against invading pathogens is critical for better understanding the pathogenesis mechanism of infectious disease.

Funder

Research Grants Council, University Grants Committee

Health and Medical Research Fund

Food and Health Bureau

Innovation and Technology Commission

National Key Research and Development Program of China

Sanming Project of Medicine in Shenzhen

High-level Hospital Construction Project of Guangdong Provincial People's Hospital

Major Science and Technology Project of Hainan Province

Hong Kong Hainan Commercial Association

Lo Ying Shek Chi Wai Foundation

University of Hong Kong

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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