Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19-Reference-Cited by-同舟云学术

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Published:2022-07-28 Issue:7928 Volume:609 Page:801-807
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Karagiannis Fotios^ORCID,Peukert Konrad,Surace Laura^ORCID,Michla Marcel,Nikolka Fabian,Fox Mario,Weiss Patricia,Feuerborn Caroline,Maier Paul^ORCID,Schulz Susanne,Al Burcu,Seeliger Benjamin^ORCID,Welte Tobias^ORCID,David Sascha,Grondman Inge,de Nooijer Aline H.^ORCID,Pickkers Peter,Kleiner Jan Lukas,Berger Marc Moritz^ORCID,Brenner Thorsten,Putensen Christian,Abdullah Zeinab,Latz Eicke,Schmidt Susanne,Hartmann Gunther,Streeck Hendrik,Kümmerer Beate M.,Kato Hiroki,Garbi Natalio,Netea Mihai G.^ORCID,Hiller Karsten^ORCID,Placek Katarzyna,Bode Christian^ORCID,Wilhelm Christoph^ORCID,

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-022-05128-8.pdf

Reference53 articles.

1. Troha, K. & Ayres, J. S. Metabolic adaptations to infections at the organismal level. Trends Immunol. 41, 113–125 (2020).

2. Wilhelm, C., Surendar, J. & Karagiannis, F. Enemy or ally? Fasting as an essential regulator of immune responses. Trends Immunol. 42, 389–400 (2021).

3. Rao, S. et al. Pathogen-mediated inhibition of anorexia promotes host survival and transmission. Cell 168, 503–516 (2017).

4. Puchalska, P. & Crawford, P. A. Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab. 25, 262–284 (2017).

5. Wang, A. et al. Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. Cell 166, 1512–1525 (2016).

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