Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors-Reference-Cited by-同舟云学术

Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors

Published:2014 Issue:12 Volume:5 Page:1821-1828
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Srimongkolpithak Nitipol¹²³⁴⁵,Sundriyal Sandeep¹²³⁴,Li Fengling⁶⁷⁸⁹,Vedadi Masoud⁶⁷⁸⁹,Fuchter Matthew J.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Imperial College London

3. London SW7 2AZ

4. UK

5. Institute of Chemical Biology

6. Structural Genomics Consortium

7. University of Toronto

8. Toronto

9. Canada

Abstract

With the aim of discovering novel G9a inhibitory chemotypes, we have identified a new quinoline inhibitor scaffold and better defined the pharmacophoric features of the central heterocycle.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00274A

Reference43 articles.

1. SET Domain-containing Protein, G9a, Is a Novel Lysine-preferring Mammalian Histone Methyltransferase with Hyperactivity and Specific Selectivity to Lysines 9 and 27 of Histone H3

2. Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells

3. Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

4. High-Resolution Profiling of Histone Methylations in the Human Genome

5. The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

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