Grafting multi-maleimides on antisense oligonucleotide to enhance its cellular uptake and gene silencing capability-Reference-Cited by-同舟云学术

Grafting multi-maleimides on antisense oligonucleotide to enhance its cellular uptake and gene silencing capability

Published:2020 Issue:54 Volume:56 Page:7439-7442
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Guo Yuanyuan¹²³⁴⁵,Zhang Jiao¹²³⁴⁵,Pan Gaifang¹²³⁴⁵,Choi Chung Hang Jonathan⁶⁷⁸⁵^ORCID,Wang Ping⁹¹⁰⁵,Li Yuehua¹¹¹²¹³¹⁴⁵,Zhu Xinyuan¹²³⁴⁵^ORCID,Zhang Chuan¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Frontiers Science Center for Transformative Molecules

3. Shanghai Jiao Tong University

4. Shanghai 200240

5. China

6. Department of Biomedical Engineering

7. The Chinese University of Hong Kong

8. New Territories

9. Weigao Research Center

10. Shanghai

11. Department of Radiology

12. Shanghai Jiao Tong University Affiliated Sixth People's Hospital

13. Shanghai Jiao Tong University School of Medicine

14. Shanghai 200233

Abstract

Grafting multi-maleimides on antisense oligonucleotide enables its click conjugation to membrane proteins, inducing promoted non-endocytic cell internalization and gene knockdown.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02548H

Reference34 articles.

1. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.

2. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

3. The Role of Environmental Carcinogens, Viruses, and Genetic

4. Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications

5. Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

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