Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies-Reference-Cited by-同舟云学术

Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies

Published:2024 Issue:2 Volume:14 Page:1018-1033
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Saeed Aamer¹^ORCID,Ahmed Atteeque¹,Haider Main Bilal¹,Ismail Hammad²,Hayat Khizar³,Shabir Ghulam¹,El-Seedi Hesham R.⁴⁵

Affiliation:

1. Department of Chemistry, Quaid I Azam University, Islamabad, 45320, Pakistan

2. Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat, 50700, Pakistan

3. Department of Botany, University of Gujrat, Gujrat, 50700, Pakistan

4. International Research Centre for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China

5. Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia

Abstract

IC50 values of the new synthesized pyrazoline-acyl thioureas revealed 5b and 5g as potent urease inhibitors. Whilst compound 5b is a potent α-glucosidase inhibitor, compound 5f is a potent amylase inhibitor, compound 5b is a potent antioxidant.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA06812A

Reference40 articles.

1. Ultrasound assisted synthesis of 5–7 membered heterocyclic rings in organic molecules

2. Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas

3. Unveiling a versatile heterocycle: pyrazoline – a review

4. Synthesis, molecular docking studies of coumarinyl-pyrazolinyl substituted thiazoles as non-competitive inhibitors of mushroom tyrosinase

5. Hybrid Pharmacophoric Approach in the Design and Synthesis of Coumarin Linked Pyrazolinyl as Urease Inhibitors, Kinetic Mechanism and Molecular Docking

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Exploring 2-Pyrazoline derivatives as potent antidiabetic agents and cholinesterase inhibitors: Their synthesis and molecular docking studies;Journal of Molecular Structure;2024-11

2. Synthesis, Crystal Structures and Urease Inhibition of Copper(II) and Zinc(II) Complexes Derived from N,N’-Bis(4-bromosalicylidene)-1,3-propanediamine;Acta Chimica Slovenica;2024-06-20

3. Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis;Frontiers in Chemistry;2024-05-24

4. Synthesis, crystal structures and urease inhibition of nickel(II), copper(II), zinc(II) and molybdenum(VI) complexes derived from N,n’ -bis(4-bromosalicylidene)-1,3-propanediamine;Journal of Coordination Chemistry;2024-05-18

5. Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review;RSC Advances;2024