4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression-Reference-Cited by-同舟云学术

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4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression

Published:2015 Issue:3 Volume:11 Page:783-790
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Faal Tannaz¹²³⁴⁵,Wong Pamela T.⁶⁷⁸⁹⁴,Tang Shengzhuang⁶⁷⁸⁹⁴,Coulter Alexa⁶⁷⁸⁹⁴,Chen Yumay¹²³⁴¹⁰,Tu Christina H.¹²³⁴,Baker James R.⁶⁷⁸⁹⁴,Choi Seok Ki⁶⁷⁸⁹⁴,Inlay Matthew A.¹²³⁴⁵

Affiliation:

1. Sue and Bill Gross Stem Cell Research Center

2. University of California Irvine

3. Irvine

4. USA

5. Department of Molecular Biology and Biochemistry

6. Department of Internal Medicine

7. Michigan Nanotechnology Institute for Medicine and Biological Sciences

8. University of Michigan

9. Ann Arbor

10. Department of Medicine

Abstract

Here, we synthesized and validated a photocaged hydroxytamoxifen molecule to achieve spatiotemporal control of gene expression with light.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C4MB00581C

Reference33 articles.

1. Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases

2. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

3. Ligand-activated site-specific recombination in mice.

4. Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains

5. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreERT to assay temporal activity windows along the proximodistal limb skeleton

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2. Towards a Light‐mediated Gene Therapy for the Eye using Caged Ethinylestradiol and the Inducible Cre/lox System;Angewandte Chemie International Edition;2024-01-23

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4. Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light‐Triggered DNA Recombination;ChemBioChem;2024-01-19

5. Potential of covalently linked tamoxifen hybrids for cancer treatment: recent update;RSC Medicinal Chemistry;2024

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