Visualizing the cellular internalization of therapeutic antibodies <i>via</i> pH-sensitive release of AIEgen-Reference-Cited by-同舟云学术

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Visualizing the cellular internalization of therapeutic antibodies via pH-sensitive release of AIEgen

Published:2024 Issue:24 Volume:22 Page:4950-4957
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Han Zai-Gang¹,He Kaifeng²³,Zheng Yi³,Qian Linghui³^ORCID

Affiliation:

1. Department of Pharmacy, Affiliated Hospital of Beihua University, Jilin 132011, China

2. Department of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China

3. Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Abstract

One-step fluorogenic labeling of antibody drugs for wash-free imaging of their cellular internalization in living cells.

Funder

National Natural Science Foundation of China

Zhejiang University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00512K

Reference30 articles.

1. The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

2. Recent progress in the molecular imaging of therapeutic monoclonal antibodies

3. Tumour-intrinsic resistance to immune checkpoint blockade

4. Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

5. Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications

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