The Bull–James assembly as a chiral auxiliary and shift reagent in kinetic resolution of alkyne amines by the CuAAC reaction-Reference-Cited by-同舟云学术

The Bull–James assembly as a chiral auxiliary and shift reagent in kinetic resolution of alkyne amines by the CuAAC reaction

Published:2016 Issue:46 Volume:14 Page:10778-10782
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Brittain William D. G.¹²³⁴⁵^ORCID,Chapin Brette M.¹²³⁴⁵,Zhai Wenlei¹²³⁴⁵,Lynch Vincent M.⁵⁶⁷⁸,Buckley Benjamin R.⁵⁹¹⁰⁴,Anslyn Eric V.⁵⁶⁷⁸,Fossey John S.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Birmingham

3. Birmingham

4. UK

5. Department of Chemistry

6. The University of Texas at Austin

7. Austin

8. USA

9. Loughborough University

10. Leicestershire

Abstract

The Bull–James boronic acid assembly is used simultaneously as a chiral auxiliary for kinetic resolution and as a chiral shift reagent for in situ enantiomeric excess (ee) determination by ¹H NMR spectroscopy.

Funder

Royal Society of Chemistry

Engineering and Physical Sciences Research Council

National Institutes of Health

China Scholarship Council

Royal Society

University Of Birmingham

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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