Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates-Reference-Cited by-同舟云学术

Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates

Published:2018 Issue:32 Volume:16 Page:5800-5807
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Milisavljevič Nemanja¹²³⁴⁵,Perlíková Pavla¹²³⁴,Pohl Radek¹²³⁴,Hocek Michal¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry

2. Czech Academy of Sciences

3. Prague 6

4. Czech Republic

5. Department of Organic Chemistry

Abstract

Synthesis and systematic study of T7 RNA polymerase incorporation of base-modified ribonucleotides for the enzymatic synthesis of modified RNA.

Funder

European Regional Development Fund

Grantová Agentura České Republiky

Akademie Věd České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01498A

Reference65 articles.

1. Natural and engineered nucleic acids as tools to explore biology

2. Oligo- and poly-nucleotides: 50 years of chemical synthesis

3. Current Challenges in Nucleic Acid Synthesis

4. Nucleoside Triphosphates — Building Blocks for the Modification of Nucleic Acids

5. Structural Insights into the Processing of Nucleobase-Modified Nucleotides by DNA Polymerases

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