Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides

Author:

Zhou Jin12345,Chang Ang12345,Wang Linlin12345,Liu Ying12345,Liu Xiangjun12345,Shangguan Dihua12345

Affiliation:

1. Beijing National Laboratory for Molecular Sciences

2. Key Laboratory of Analytical Chemistry for Living Biosystems

3. Institute of Chemistry

4. Chinese Academy of Sciences

5. Beijing, 100190, China

Abstract

The guanidinoethyl group increases DNA binding, and decreases the cell permeability and cytotoxity; the dimethylaminopropyl group enhances the cell permeability and cytotoxity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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