Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo

Author:

Schueffl Hemma1ORCID,Theiner Sarah2ORCID,Hermann Gerrit2,Mayr Josef3,Fronik Philipp3,Groza Diana1,van Schonhooven Sushilla1,Galvez Luis2,Sommerfeld Nadine S.3,Schintlmeister Arno4ORCID,Reipert Siegfried5,Wagner Michael4,Mader Robert M.6ORCID,Koellensperger Gunda2,Keppler Bernhard K.37,Berger Walter16ORCID,Kowol Christian R.36ORCID,Legin Anton3ORCID,Heffeter Petra16

Affiliation:

1. Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria

2. Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 38, A-1090 Vienna, Austria

3. Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria

4. Centre for Microbiology and Environmental Systems Science, Division of Microbial Ecology and Large-Instrument Facility for Environmental and Isotope Mass Spectrometry, University of Vienna, Djerassiplatz 1, A-1030 Vienna, Austria

5. Core Facility Cell Imaging and Ultrastructure Research, University of Vienna, University Biology Building (UBB), Djerassiplatz 1, A-1030 Vienna, Austria

6. Department of Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria

7. Research Cluster “Translational Cancer Therapy Research”, University of Vienna, Medical University of Vienna, Vienna, Austria

Abstract

Albumin-targeting of a maleimide-containing oxaliplatin-releasing platinum(iv) prodrug results in tumor-specific drug delivery and activity as shown by LA-ICP-MS, isotope-labeling and NanoSIMS in cell culture and in vivo.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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