Stepwise optimization of tumor-targeted dual-action platinum(<scp>iv</scp>)-gemcitabine prodrugs-Reference-Cited by-同舟云学术

Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs

Published:2024 Issue:2 Volume:11 Page:534-548
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Kastner Alexander¹²^ORCID,Mendrina Theresa¹³,Babu Tomer⁴^ORCID,Karmakar Subhendu⁴^ORCID,Poetsch Isabella¹³,Berger Walter³⁵^ORCID,Keppler Bernhard K.¹⁵,Gibson Dan⁴^ORCID,Heffeter Petra³⁵^ORCID,Kowol Christian R.¹⁵^ORCID

Affiliation:

1. University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, 1090 Vienna, Austria

2. University of Vienna, Vienna Doctoral School in Chemistry (DoSChem), Waehringer Str. 42, 1090 Vienna, Austria

3. Center of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria

4. Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, 9112102 Jerusalem, Israel

5. Research Cluster “Translational Cancer Therapy Research”, 1090 Vienna, Austria

Abstract

An albumin-binding cisplatin(iv)-gemcitabine complex was step-by-step improved based on stability, reduction, albumin-binding and in vivo data yielding a carboplatin(iv) complex with distinctly improved overall survival and anticancer activity.

Funder

Austrian Science Fund

Israel Science Foundation

Council for Higher Education of Israel

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QI/D3QI02032K

Reference33 articles.

1. WHO, Cancer, https://www.who.int/news-room/fact-sheets/detail/cancer