The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines-Reference-Cited by-同舟云学术

The kinetics and mechanism of the organo-iridium-catalysed enantioselective reduction of imines

Published:2016 Issue:14 Volume:14 Page:3614-3622
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Stirling Matthew J.¹²³⁴⁵,Sweeney Gemma¹²³⁴⁵,MacRory Kerry¹²³⁴⁵,Blacker A. John⁶⁷⁸⁹¹⁰,Page Michael I.¹²³⁴⁵

Affiliation:

1. IPOS

2. The Page Laboratories

3. Department of Chemical and Biological Sciences

4. The University of Huddersfield

5. Huddersfield

6. Institute of Process Research & Development

7. School of Chemistry

8. University of Leeds

9. Leeds

10. UK

Abstract

The enantiomeric excess (ee) for the organo-iridium catalysed reduction of imines decreases during the reaction because the rate of formation of the (R)-product amine follows first-order kinetics whereas that for the (S)-enantiomer is zero-order.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00245E

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