Investigation into the bioavailability of milk protein-derived peptides with dipeptidyl-peptidase IV inhibitory activity using Caco-2 cell monolayers-Reference-Cited by-同舟云学术

Investigation into the bioavailability of milk protein-derived peptides with dipeptidyl-peptidase IV inhibitory activity using Caco-2 cell monolayers

Published:2017 Issue:2 Volume:8 Page:701-709
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Lacroix Isabelle M. E.¹²³⁴⁵,Chen Xiu-Min¹²³⁴⁵,Kitts David D.¹²³⁴⁵,Li-Chan Eunice C. Y.¹²³⁴⁵^ORCID

Affiliation:

1. The University of British Columbia

2. Faculty of Land & Food Systems

3. Food Nutrition & Health Program

4. Vancouver

5. Canada V6T 1Z4

Abstract

The present study used Caco-2 cell monolayers to investigate the bioavailability of milk protein-derived peptides with DPP-IV inhibitory activity and showed that the susceptibility of the peptides to brush border membrane peptidases impacts their biological activity.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2017/FO/C6FO01411A

Reference28 articles.

1. The pharmacokinetic considerations and adverse effects of DDP-4 inhibitors

2. Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas

3. Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations