Formulation of milk protein-derived dipeptidyl peptidase-IV inhibitory peptides rich dietary supplement: Opportunities and Challenges

Abstract

Sedentary lifestyle and diet are widely recognised as key risk factors for chronic illnesses like type-2 diabetes. As consumers’ food choices are increasingly influenced by nutritional, environmental and health factors, the scientific community focuses on identifying natural bioactive chemicals. Since dairy protein-derived, bioactive peptides can be used as nutraceuticals and medications to treat metabolic disorders with few or no human side effects. In this context, extensive research conducted in the dairy industry over the past two decades has demonstrated that milk proteins, including an abundance of peptides, possess biological features that can mitigate diabetes. Preclinical and clinical research has found some excellent peptides with superior efficacy and safety. Thus, more research on these peptides may lead to clinically beneficial antidiabetics. This chapter gives detailed development of DPP-IV inhibitory-rich dietary supplements.