Glycosidase activated prodrugs for targeted cancer therapy

Author:

Martin Harlei1ORCID,Lázaro Laura Ramírez12ORCID,Gunnlaugsson Thorfinnur12ORCID,Scanlan Eoin M.12

Affiliation:

1. School of Chemistry and Trinity Bioscience Institute, The University of Dublin, Trinity College Dublin, Dublin 2, Ireland

2. SFI Synthesis and Solid State Pharmaceutical Centre (SSPC), Ireland

Abstract

In this review glycosidase activated prodrugs that target cancer cells are discussed.

Funder

Irish Research Council

Science Foundation Ireland

Trinity College Dublin

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference111 articles.

1. World Health Organisation , Cancer , https://www.who.int/news-room/fact-sheets/detail/cancer , accessed 20/01/2022, 2022

2. National Cancer Institute at the National Institutes of Health, Cancer Statistics , https://www.cancer.gov/about-cancer/understanding/statistics , accessed 20/01/2022, 2020

3. S. N.Khleif , O.Rixe and R.Skeel , Skeel's Handbook of Cancer Therapy , Wolters Kluwer Health , 2016

4. Chemical Aspects of Selective Toxicity

5. Prodrugs

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