Amidino substituted 2-aminophenols: biologically important building blocks for the amidino-functionalization of 2-substituted benzoxazoles

Author:

Ptiček Lucija12345,Hok Lucija6745ORCID,Grbčić Petra8910115,Topić Filip12131415,Cetina Mario12345ORCID,Rissanen Kari12131415ORCID,Pavelić Sandra Kraljević1610115,Vianello Robert6745ORCID,Racané Livio12345ORCID

Affiliation:

1. Department of Applied Chemistry

2. Faculty of Textile Technology

3. University of Zagreb

4. 10000 Zagreb

5. Croatia

6. Division of Organic Chemistry and Biochemistry

7. Ruđer Bošković Institute

8. Department of Biotechnology

9. Centre for high-throughput technologies

10. University of Rijeka

11. 51000 Rijeka

12. University of Jyvaskyla

13. Department of Chemistry

14. 40014 Jyväskylä

15. Finland

16. Faculty of Health Studies

Abstract

A new synthetic strategy involving the Pinner reaction offers various amidino-functionalized 2-substituted benzoxazoles via amidino-substituted 2-aminophenols with sub-micromolar antiproliferative activities.

Funder

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference36 articles.

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3. Design of DNA Minor Groove Binding Diamidines That Recognize GC Base Pair Sequences:  A Dimeric-Hinge Interaction Motif

4. Designed Compounds for Recognition of 10 Base Pairs of DNA with Two AT Binding Sites

5. Systematic synthetic and biophysical development of mixed sequence DNA binding agents

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