Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity-Reference-Cited by-同舟云学术

Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity

Published:2023-06-05 Issue:13 Volume:88 Page:9469-9474
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Skrzypczak Natalia¹,Pyta Krystian¹²,Bohusz Wiktor¹,Leśniewska Aleksandra¹^ORCID,Gdaniec Maria¹^ORCID,Ruszkowski Piotr³,Schilf Wojciech⁴,Bartl Franz²,Przybylski Piotr¹^ORCID

Affiliation:

1. Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland

2. Lebenswissenschaftliche Fakultät, Institut für Biologie, Biophysikalische Chemie Humboldt-Universität zu Berlin, Invalidenstraße 42, 10115 Berlin, Germany

3. Department of Pharmacology, Poznań University of Medical Sciences, Rokietnicka 5a, 60-806 Poznań, Poland

4. Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

Funder

Narodowe Centrum Nauki

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00493

Reference43 articles.

1. Modifications, biological origin and antibacterial activity of naphthalenoid ansamycins

2. Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners

3. The chemistry and biology of the maytansinoid antitumor agents

4. Ansamycin antibioticsA discovery, classification, biosynthesis and biological activities

5. Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy

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