Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP-Reference-Cited by-同舟云学术

Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP

Published:2022 Issue:22 Volume:13 Page:11770-11779
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Geng Qinghe¹²³^ORCID,Wang Shen⁴,Heng Ke⁵,Zhai Juan³,Song Xingchen³,Xia Lei⁶,Wang Lulu⁶,Lin Qiang⁷,Li Hongwei⁷,Guo Yilong³

Affiliation:

1. Cancer Institute, Xuzhou Medical University, Xuzhou, China

2. Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

3. Central Lab, Pizhou Hospital, Xuzhou Medical University, Xuzhou, China

4. Peking University People's Hospital, Beijing, China

5. Department of Orthopedics, Changzhou Second Hospital, Nanjing Medical University, Changzhou, China

6. Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

7. Department of Orthopedics, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

Abstract

Astaxanthin can correct osteoporotic phenotypes, caused by irradiation, by inhibiting oxidative stress, DNA damage, osteocyte senescence and SASP, subsequently promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption.

Funder

China Postdoctoral Science Foundation

Jiangsu Commission of Health

Xuzhou Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO01673G

Reference64 articles.

1. Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation

2. Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells

3. Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity

4. Implant survival in mandibles of irradiated oral cancer patients

5. Total-Body Irradiation of Postpubertal Mice with137Cs Acutely Compromises the Microarchitecture of Cancellous Bone and Increases Osteoclasts

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