Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum: discovery of a cysteine-targeted Michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions-Reference-Cited by-同舟云学术

Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum: discovery of a cysteine-targeted Michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions

Published:2015 Issue:86 Volume:5 Page:70595-70603
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Darsih Cici¹²³⁴,Prachyawarakorn Vilailak⁵³⁴,Wiyakrutta Suthep⁶⁷⁸⁹⁴,Mahidol Chulabhorn¹²³⁴⁵,Ruchirawat Somsak¹²³⁴⁵,Kittakoop Prasat¹²³⁴⁵

Affiliation:

1. Chulabhorn Graduate Institute

2. Chemical Biology Program

3. Bangkok 10210

4. Thailand

5. Chulabhorn Research Institute

6. Department of Microbiology

7. Faculty of Science

8. Mahidol University

9. Bangkok 10400

Abstract

A novel tetracyclic polyketide uniquely spiro-attached with a γ-lactone ring and a potent cytotoxic agent possessing a thiol-reactive pharmacophore were isolated from the mangrove endophytic fungus Penicillium chermesinum.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA13735G

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