Tobramycin-mediated self-assembly of DNA nanostructures for targeted treatment of <i>Pseudomonas aeruginosa</i>-infected lung inflammation-Reference-Cited by-同舟云学术

Tobramycin-mediated self-assembly of DNA nanostructures for targeted treatment of Pseudomonas aeruginosa-infected lung inflammation

Published:2024 Issue:9 Volume:12 Page:2331-2340
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Xu Yuhang¹,Liu Qian¹²^ORCID,Wang Bin¹³,Li Quan¹,Chen Yue¹,Yang Yao¹,Zhu Zhihao¹,Gong Daohui¹,Zhang Chuan⁴^ORCID,Wang Guansong¹³,Qian Hang¹³^ORCID

Affiliation:

1. Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

2. Laboratory of Pharmacy and Chemistry, and Laboratory of Tissue and Cell Biology, Lab Teaching & Management Center, Chongqing Medical University, Chongqing, 400016, China

3. Chongqing Key Laboratory of Precision Medicine and Prevention of Major Respiratory Diseases, Chongqing 400037, China

4. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

Abstract

A magnesium-free assembly method that utilizes tobramycin as a mediator to assemble DNA nanostructures is proposed. Targeting of PA is achieved by incorporating maleimide-modified DNA into the nanostructures, directed towards the pili of PA.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Chongqing

Army Medical University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM02121A

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