CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection-Reference-Cited by-同舟云学术

CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection

Published:2019-07-03 Issue:499 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Riquelme Sebastián A.¹^ORCID,Lozano Carmen²^ORCID,Moustafa Ahmed M.³^ORCID,Liimatta Kalle¹^ORCID,Tomlinson Kira L.¹^ORCID,Britto Clemente⁴^ORCID,Khanal Sara⁴^ORCID,Gill Simren K.¹,Narechania Apurva⁵,Azcona-Gutiérrez Jose M.⁶^ORCID,DiMango Emily⁷,Saénz Yolanda²^ORCID,Planet Paul³^ORCID,Prince Alice¹^ORCID

Affiliation:

1. Department of Pediatrics, Columbia University, New York, NY 10032, USA.

2. Area de Microbiología Molecular, Centro de Investigación Biomédica de la Rioja (CIBIR), Microbiología Molecular, Logroño, LG 26006, Spain.

3. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

4. Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

5. American Museum of Natural History, New York, NY 10024, USA.

6. Departamento de Diagnóstico Biomédico. Laboratorio de Microbiología, Hospital San Pedro, Logroño, LG 26006, Spain.

7. Department of Medicine, Columbia University, New York, NY 10032, USA.

Abstract

Excess succinate due to CFTR-PTEN dysfunction selects for Pseudomonas aeruginosa mutants adapted to the airway.

Funder

NIH Office of the Director

Cystic Fibrosis Foundation

Pediatric Infectious Diseases Society

Instituto de Salud Carlos III

NCATS-NIH