Structure and activity study of tripeptide IRW in TNF-α induced insulin resistant skeletal muscle cells-Reference-Cited by-同舟云学术

Structure and activity study of tripeptide IRW in TNF-α induced insulin resistant skeletal muscle cells

Published:2022 Issue:7 Volume:13 Page:4061-4068
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Jiang Xu¹^ORCID,Wu Jianping¹^ORCID

Affiliation:

1. Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Building, University of Alberta, Edmonton, Alberta T6G 2P5, Canada

Abstract

IRW was found to improve TNF-α induced insulin resistance. IRW analog IRA and derivative IR reversed the increased tyrosine residue of IRS and decreased serine residue of IRS induced by TNF-α. Thus, IRW, IR and IRA improved the GLUT4 translocation.

Funder

Natural Sciences and Engineering Research Council of Canada

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO02893F

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