Investigation of the molecular and mechanistic basis for the regioselective metabolism of midazolam by cytochrome P450 3A4
Author:
Affiliation:
1. Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun, 130023, China
2. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, 130023, China
Abstract
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP00232A
Reference58 articles.
1. Structure and Chemistry of Cytochrome P450
2. Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review
3. The Stereoselective Oxidation of para ‐Substituted Benzenes by a Cytochrome P450 Biocatalyst
4. Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation
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