Assessing the role of residue Phe108 of cytochrome P450 3A4 in allosteric effects of midazolam metabolism-Reference-Cited by-同舟云学术

Assessing the role of residue Phe108 of cytochrome P450 3A4 in allosteric effects of midazolam metabolism

Published:2024 Issue:11 Volume:26 Page:8807-8814
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Fu Tingting¹²,Zhang Hongxing²,Zheng Qingchuan¹²^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China

2. Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun, 130023, China

Abstract

Residue F108 of CYP3A4 is closely related to substrate binding stability, the transition of substrate binding mode, and the characteristics of CYP3A4 channels, playing an important role in MDZ metabolism and allosteric effects.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CP/D3CP05270B

Reference46 articles.

1. Cytochrome P450 structure–function: insights from molecular dynamics simulations

2. Cytochrome P450 Enzymes and Drug Metabolism in Humans

3. Computational Investigation of Ligand Binding to the Peripheral Site in CYP3A4: Conformational Dynamics and Inhibitor Discovery

4. Functional Gene Variants of CYP3A4

5. Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

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