Structural Models of Human Norepinephrine Transporter Ensemble Reveal the Allosteric Sites and Ligand-Binding Mechanism-Reference-Cited by-同舟云学术

Structural Models of Human Norepinephrine Transporter Ensemble Reveal the Allosteric Sites and Ligand-Binding Mechanism

Published:2024-08-29 Issue:36 Volume:128 Page:8651-8661
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Luo Ding¹^ORCID,Zhang Yang²,Li Yinghong³,Liu Zerong⁴^ORCID,Wu Haibo⁵,Xue Weiwei¹^ORCID

Affiliation:

1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China

2. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China

3. Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing 400065, China

4. Central Nervous System Drug Key Laboratory of Sichuan Province, Sichuan Credit Pharmaceutical Co., Ltd., Luzhou 646000, China

5. School of Life Sciences, Chongqing University, Chongqing 401331, China

Funder

Natural Science Foundation of Chongqing Municipality

Central Nervous System Drug Key Laboratory of Sichuan Province

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.4c03731

Reference66 articles.

1. Monoamine transporters: structure, intrinsic dynamics and allosteric regulation

2. The Functional Impact of SLC6 Transporter Genetic Variation

3. Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study

4. What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation

5. Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters