The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake-Reference-Cited by-同舟云学术

The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake

Published:2022 Issue:2 Volume:13 Page:639-648
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Itaya Mayuko¹,Miyazawa Taiki²,Khalifa Saoussane¹,Shimizu Naoki¹,Nakagawa Kiyotaka¹^ORCID

Affiliation:

1. Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, 468-1Aramakiazaaoba, Aoba-ku, Sendai, 980-8572, Japan

2. New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aramaki Aza-Aoba, Aoba-ku, Sendai 980-8579, Japan

Abstract

Based on the free drug hypothesis, we hypothesized that food compounds that bind stronger to BSA than CUR inhibit the binding between BSA and CUR, and that this results in an increase of the cellular uptake and physiological activities of CUR.

Funder

Japan Society for the Promotion of Science

Asahi Group Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO03234H

Reference44 articles.

1. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

2. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities