Synergetic enhancement of antitumor efficacy with charge-reversal and reduction-sensitive polymer micelles-Reference-Cited by-同舟云学术

Synergetic enhancement of antitumor efficacy with charge-reversal and reduction-sensitive polymer micelles

Published:2016 Issue:32 Volume:7 Page:5113-5122
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Li Shi-Xi¹²³⁴⁵,Liu Lei¹²³⁴⁵,Zhang Liu-Jie¹²³⁴⁵,Wu Bo¹²³⁴⁵,Wang Cai-Xia¹²³⁴⁵,Zhou Wei¹²³⁴⁵,Zhuo Ren-Xi¹²³⁴⁵,Huang Shi-Wen¹²³⁴⁵

Affiliation:

1. Key Laboratory of Biomedical Polymers

2. Ministry of Education

3. Department of Chemistry

4. Wuhan University

5. Wuhan 430072

Abstract

An amphiphilic block copolymer PLA-SS-PAEMA/DMMA was used to encapsulate and deliver Doxorubicin for synergetic enhancement of antitumor efficacy by the combinational effect of charge-reversal on cellular uptake and reduction-sensitivity on intracellular DOX release.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2016/PY/C6PY00874G

Reference28 articles.

1. Principles of nanoparticle design for overcoming biological barriers to drug delivery

2. Effect of pegylation on pharmaceuticals

3. Self-Assembled Smart Nanocarriers for Targeted Drug Delivery