Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen-Reference-Cited by-同舟云学术

Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen

Published:2021 Issue:86 Volume:57 Page:11382-11385
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Fuentes Roberto¹^ORCID,Aguinagalde Leire¹^ORCID,Sacristán Nagore¹,Fernández-Tejada Alberto¹²^ORCID

Affiliation:

1. Chemical Immunology Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160 Derio, Spain

2. Ikerbasque, Basque Foundation for Science, Euskadi Plaza 5, 48009 Bilbao, Spain

Abstract

Versatile chemical strategy for the development of novel conjugates based on streamlined saponin adjuvants covalently linked to a synthetic antigen (Tn) that induced moderate antibody responses in mice.

Funder

H2020 European Research Council

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC04459A

Reference32 articles.

1. Immunotherapy for cancer: synthetic carbohydrate-based vaccines

2. A Vision for Vaccines Built from Fully Synthetic Tumor-Associated Antigens: From the Laboratory to the Clinic

3. Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

4. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review

5. Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

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