Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen-Reference-Cited by-同舟云学术

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Published:2023 Issue:13 Volume:14 Page:3501-3513
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Pifferi Carlo¹^ORCID,Aguinagalde Leire¹^ORCID,Ruiz-de-Angulo Ane¹,Sacristán Nagore¹,Baschirotto Priscila Tonon¹,Poveda Ana²^ORCID,Jiménez-Barbero Jesús²³⁴⁵^ORCID,Anguita Juan³⁶^ORCID,Fernández-Tejada Alberto¹³^ORCID

Affiliation:

1. Chemical Immunology Laboratory, Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Biscay Technology Park, Building 801A, 48160 Derio, Spain

2. Chemical Glycobiology Laboratory, CIC BioGUNE, BRTA, Spain

3. Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 13, 48009 Bilbao, Spain

4. Department of Organic Chemistry II, Faculty of Science & Technology, University of the Basque Country, 48940 Leioa, Spain

5. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain

6. Inflammation and Macrophage Plasticity Laboratory, CIC BioGUNE, BRTA, Spain

Abstract

Synthesis, immuno-evaluation in mice, and NMR studies of new, self-adjuvanting, and self-assembling tri-component vaccines based on a synthetic saponin adjuvant chemically conjugated to TA-MUC1 (glyco)peptide antigens and a helper T-cell epitope.

Funder

H2020 European Research Council

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC05639A

Reference86 articles.

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