What can reaction databases teach us about Buchwald–Hartwig cross-couplings?-Reference-Cited by-同舟云学术

What can reaction databases teach us about Buchwald–Hartwig cross-couplings?

Published:2020 Issue:48 Volume:11 Page:13085-13093
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fitzner Martin¹²³⁴⁵^ORCID,Wuitschik Georg¹⁶³⁴⁵^ORCID,Koller Raffael J.¹⁶³⁴⁵^ORCID,Adam Jean-Michel¹⁶³⁴⁵,Schindler Torsten¹²³⁴⁵,Reymond Jean-Louis⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Roche Pharma Research and Early Development

2. pRED Informatics

3. Roche Innovation Center Basel

4. F. Hoffmann-La Roche Ltd

5. CH-4070 Basel

6. pCMC Drug Substance

7. Department of Chemistry and Biochemistry

8. University of Bern

9. 3012 Bern

10. Switzerland

Abstract

An analysis of the entire literature on Pd-catalyzed C–N couplings enables data-driven insight and provides recommendations for reaction conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC04074F

Reference34 articles.

1. PALLADIUM-CATALYZED AROMATIC AMINATION OF ARYL BROMIDES WITHN,N-DI-ETHYLAMINO-TRIBUTYLTIN

2. Palladium-Catalyzed Aromatic Aminations with in situ Generated Aminostannanes

3. A Simple Catalytic Method for the Conversion of Aryl Bromides to Arylamines

4. Palladium-catalyzed formation of carbon-nitrogen bonds. Reaction intermediates and catalyst improvements in the hetero cross-coupling of aryl halides and tin amides

5. Palladium-catalyzed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents

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