Synthesis and anticancer evaluation of acetylated-lysine conjugated gemcitabine prodrugs-Reference-Cited by-同舟云学术

Synthesis and anticancer evaluation of acetylated-lysine conjugated gemcitabine prodrugs

Published:2023 Issue:8 Volume:14 Page:1572-1580
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Wang Mengmeng¹,Qu Kunyu¹,Zhao Peipei¹,Yin Xin¹,Meng Yiwei¹,Herdewijn Piet²^ORCID,Liu Chao³^ORCID,Zhang Lixin¹⁴,Xia Xuekui¹^ORCID

Affiliation:

1. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China

2. Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium

3. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China

4. State Key Laboratory of Bioreactor Engineering, and School of Biotechnology, East China University of Science and Technology (ECUST), Shanghai 200237, China

Abstract

We report a series of acetylated lysine conjugated gemcitabine prodrugs that exhibit highly selective tumor cell growth inhibition and enhanced metabolic stability.

Funder

Natural Science Foundation of Shandong Province

High-end Foreign Experts Recruitment Plan of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00190C

Reference28 articles.

1. Gemcitabine in metastatic breast cancer

2. Molecular predictors of gemcitabine response in pancreatic cancer

3. Systemic Chemotherapy for Advanced Non-Small Cell Lung Cancer: Recent Advances and Future Directions

4. Design, synthesis, and evaluation of liver-specific gemcitabine prodrugs for potential treatment of hepatitis C virus infection and hepatocellular carcinoma

5. Small Molecular Gemcitabine Prodrugs for Cancer Therapy

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