“Click and go”: simple and fast folic acid conjugation-Reference-Cited by-同舟云学术

“Click and go”: simple and fast folic acid conjugation

Published:2014 Issue:20 Volume:12 Page:3181-3190
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Trindade Alexandre F.¹²³⁴⁵,Frade Raquel F. M.⁶⁷⁸⁹,Maçôas Ermelinda M. S.¹²³⁴⁵,Graça Cátia¹²³⁴⁵,Rodrigues Catarina A. B.¹²³⁴⁵,Martinho José M. G.¹²³⁴⁵,Afonso Carlos A. M.⁶⁷⁸⁹

Affiliation:

1. CQFM

2. Centro de Química-Física Molecular

3. IN-Institute of Nanosciences and Nanotechnology

4. Instituto Superior Técnico

5. 1049-001 Lisboa, Portugal

6. Instituto de Investigação do Medicamento (iMed.ULisboa)

7. Faculdade de Farmácia

8. Universidade de Lisboa

9. 1649-003 Lisboa, Portugal

Abstract

A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne–azide cycloaddition, without the need for expensive chromatographic purifcation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00150H

Reference56 articles.

1. The role of folate receptor α in cancer development, progression and treatment: Cause, consequence or innocent bystander?

2. Targeted drug delivery via the folate receptor

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