Affiliation:
1. MIREA - Russian Technology University (Lomonosov Institute of Fine Chemical Technology)
Abstract
Recently, due to the growth of bacterial infections resistant to antibiotics, there is an urgent need to develop alternative antibacterial drugs. Alkyl-indolyl-L-lysine is a promising class of compounds; their amphiphilic structure is key in antimicrobial ef cacy. A scheme was developed and the synthesis of ve new derivatives of indolylbutyric and indolylacetic acids containing a polar amino acid residue with an ethylenediamine linker binding alkyl fragments of different lengths was carried out. The antibacterial activity of new amphiphiles against gram-positive and gram-negative bacterial strains was evaluated. The minimum binding energy of synthesized compounds with human serum albumin (HSA) was determined by the method of molecular docking. A lower af nity of the studied objects was shown compared to the control indolmycin.