Novel<i>N</i>-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks-Reference-Cited by-同舟云学术

NovelN-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks

Published:2022-12-01 Issue:1 Volume:38 Page:246-266
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Philoppes John N.¹,Abdelgawad Mohamed A.²,Abourehab Mohammed A. S.³,Sebak Mohamed⁴,A. Darwish Mostafa⁵,Lamie Phoebe F.¹

Affiliation:

1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

2. Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia

3. Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

4. Microbiology and Immunology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt

Funder

the Deanship of Scientific Research at Umm Al-Qura University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2145283

Reference55 articles.

1. Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

2. Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

3. Novel N -substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study

4. Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

5. Prodrugs of Non-steroidal Anti-inflammatory Drugs (NSAIDs): A Long March Towards Synthesis of Safer NSAIDs

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